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Study identifier: NCT07270666 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

ctDNA Testing to Inform Standard-of-Care Treatment Decisions in People With Endometrial Cancer

Condition: Endometrial Cancer  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhaseNA
Planned participants30
Who can joinFemale, 18 Years to no upper limit
Healthy volunteersNo

About this study

The researchers are doing this study to evaluate the use of circulating tumor DNA (ctDNA) testing in making treatment decisions for advanced/recurrent endometrial cancer that has a change (mutation) in the mismatch repair deficient (MMR-D) gene or microsatellite instability high (MSI-H) gene. The researchers will see how doctors and their patients use the results of ctDNA testing after 1 year of standard chemotherapy and immune checkpoint inhibitor (ICI) treatment to decide whether to continue maintenance ICI treatment past 1 year. The researchers will also look at the health outcomes of people in this study (for example, whether they are cancer free at the end of their participation in the study).

This description comes directly from the study's public registry record.

Talk to the study team

Ying Liu, MD, MPH  ·  646-888-4946  ·  liuy6@mskcc.org

Paul Johannet, MD  ·  646-888-5327

Always discuss trial participation with your own doctor first.

Locations (7)

Memorial Sloan Kettering Basking Ridge (All Protocol Activites)Basking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth (All Protocol Activities)Middletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen (All Protocol Activities)Montvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)Commack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester (All Protocol Activities)Harrison, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
Memorial Sloan Kettering Nassau (All Protocol Activities)Rockville Centre, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07270666