Condition: Glioblastoma (GBM) · Brain Metastasases · Sponsor: Nader Sanai
This will be an open-label Phase 0/1 study that will enroll approximately 15 participants, 9 participants with recurrent WHO Grade 4 glioma (rGBM) and 6 participants with brain metastases, who will receive the investigational drug risvutatug rezetecan (GSK5764227), a B7-H3-targeted antibody-drug conjugate (ADC) with the GSK5757810 payload. The trial will consist of a Phase 0 component (subdivided into Arms A and B) and an Expansion Phase 1 component. Participants with tumors demonstrating a positive pharmacokinetic (PK) response in the Phase 0 component will be eligible to enroll in the Expansion Phase to receive therapeutic dosing of risvutatug rezetecan.
This description comes directly from the study's public registry record.
Phase 0 Navigator · 602-406-8605 · research@ivybraintumorcenter.org
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| St. Joseph's Hospital and Medical Center | Phoenix, Arizona, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07268053