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Study identifier: NCT07266831 Synced from ClinicalTrials.gov · July 29, 2026
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A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

Condition: Human Immunodeficiency Virus Type 1 (HIV-1) Infection  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 2/Phase 3
Planned participants570
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Researchers are looking for new ways to treat HIV-1 (Human Immunodeficiency Virus Type 1). The usual (standard) treatment for HIV-1 is antiretroviral therapy (ART), which includes taking medicines to lower the amount of HIV-1 in the body. Standard ART helps people live longer, but people must take up to 3 medicines up to twice a day. Standard ART may also cause other health problems. Researchers want to know if a study ART works as well as a standard ART to treat HIV-1. The study ART combines 2 medicines, islatravir and ulonivirine, and is taken once a week. The goals of this study are to learn: 1) If the study ART works as well as a standard ART to treat HIV-1, and 2) About the safety of the study ART and if people tolerate it compared to a standard ART.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (55)

Ruane Clinical Research Group, Inc. ( Site 1513)Los Angeles, California, United StatesRecruiting
Vivent Health ( Site 1519)Denver, Colorado, United StatesRecruiting
Whitman-Walker Institute ( Site 1538)Washington D.C., District of Columbia, United StatesRecruiting
Midway Immunology and Research Center ( Site 1503)Ft. Pierce, Florida, United StatesRecruiting
CAN Community Health- Miami Gardens ( Site 1549)Miami Gardens, Florida, United StatesRecruiting
Orlando Immunology Center ( Site 1501)Orlando, Florida, United StatesRecruiting
CAN Community Health ( Site 1510)Sarasota, Florida, United StatesRecruiting
Triple O Research Institute ( Site 1505)West Palm Beach, Florida, United StatesRecruiting
Metro Infectious Diseases Consultants L.L.C. ( Site 1509)Decatur, Georgia, United StatesRecruiting
Mercer university, Department of internal medicine-Clinical Research ( Site 1512)Macon, Georgia, United StatesRecruiting
Rush University Medical Center-Infectious Disease ( Site 1522)Chicago, Illinois, United StatesRecruiting
Henry Ford Hospital ( Site 1535)Detroit, Michigan, United StatesRecruiting

+ 43 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07266831