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Study identifier: NCT07262619 Synced from ClinicalTrials.gov · July 27, 2026
● Recruiting

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors

Condition: Advanced Solid Tumors · MSI-H or dMMR Advanced Solid Tumors · MSI-H/dMMR Gastric Cancer  ·  Sponsor: Eikon Therapeutics

PhasePhase 1/Phase 2
Planned participants160
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to determine the most effective dose of EIK1005 that a person can take safely. Additionally, this study will test how well EIK1005 is tolerated alone and in combination with pembrolizumab in treating patients with advanced cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Ana C Mamede, PharmD  ·  347-806-4584  ·  mamedea@eikontx.com

Krishna Kaza  ·  kazak@eikontx.com

Always discuss trial participation with your own doctor first.

Locations (10)

Morristown Medical CenterMorristown, New Jersey, United StatesNot Yet Recruiting
Memorial Sloan Kettering Cancer Center (MSKCC)New York, New York, United StatesNot Yet Recruiting
University of Texas MD Anderson Cancer CenterHouston, Texas, United StatesRecruiting
GenesisCare North Shore (Oncology)Saint Leonards, New South Wales, AustraliaNot Yet Recruiting
Calvary Mater Newcastle HospitalWaratah, New South Wales, AustraliaRecruiting
Grampians HealthBallarat, Victoria, AustraliaRecruiting
Chris O'Brien Lifehouse (Sydney Cancer Centre)Camperdown, Victoria, AustraliaRecruiting
Oncology Clinics Victoria (OCV) - Cabrini Brighton HospitalFrankston, Victoria, AustraliaNot Yet Recruiting
Peninsula and Southeast Oncology (PASO) MedicalFrankston, Victoria, AustraliaRecruiting
Health New ZealandWellington, New ZealandRecruiting

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Source record: clinicaltrials.gov/study/NCT07262619