Condition: Neonates and Preterm Infants · Infant Respiratory Distress Syndrome · Surfactant Deficiency Syndrome Neonatal · Sponsor: Medical University of Graz
Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA) technique. However, the optimal duration of surfactant instillation during LISA has never been systematically evaluated. Rapid instillation may provoke transient hypoxia and bradycardia, while slower administration might improve physiological stability and cerebral oxygenation. This randomised controlled trial investigates whether the duration of surfactant administration (1 minute versus 5 minutes) affects cerebral and systemic oxygen stability in extremely preterm neonates (\< 28 weeks).
This description comes directly from the study's public registry record.
Christina H. Wolfsberger, Priv.Doz. DDr. · +43 316 385 81135 · christina.wolfsberger@medunigraz.at
Gerhard Pichler, Univ.Prof. PD. Dr. · +43 316 385 80520 · gerhard.pichler@medunigraz.at
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| Medical University of Graz, Division of Neonatology, Department of Pediatrics and Adolescent Medicine | Graz, Austria | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07261787