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Study identifier: NCT07259538 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Phase I Study Evaluating the Safety, Tolerability, and Pharmacokinetics of VVN432 Nasal Spray

Condition: Chronic Rhinosinusitis (CRS)  ·  Sponsor: VivaVision Biotech, Inc

PhasePhase 1
Planned participants60
Who can joinAll sexes, 18 Years to 55 Years
Healthy volunteersYes

About this study

The goal of this clinical study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of VVN432 Nasal Spray in healthy volunteers (Phase Ia) and in patients with chronic rhinosinusitis (Phase 1b). This study consists of two parts (Phase 1a and Phase 1b): Phase 1a (SAD) is a single-center, randomized, double-masked, vehicle-controlled study to assess the safety, tolerability, and PK of VVN432 Nasal Spray in healthy adult subjects. Phase 1b (MAD) is a multi-center, randomized, double-masked, vehicle-controlled study to assess the safety, tolerability, PK/PD, and preliminary efficacy of VVN432 Nasal Spray in patients with chronic rhinosinusitis.

This description comes directly from the study's public registry record.

Talk to the study team

Caroline Lu  ·  86-18816562189  ·  caroline.lu@vivavisionbio.com

Always discuss trial participation with your own doctor first.

Locations (1)

Beijing Toren HospitalBeijing, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07259538