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Study identifier: NCT07258108 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Sac-TMT Plus KL-A167 in PD-L1+, HR+/HER2- Metastatic Breast Cancer After CDK4/6 Inhibitors

Condition: Breast Cancer  ·  Sponsor: Sun Yat-sen University

PhasePhase 2
Planned participants35
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This is a Phase II single-arm study designed to evaluate the efficacy and safety of Sac-TMT + KL-A167 in 35 patients with PD-L1+, HR+/HER2- metastatic breast cancer who previously treated with CDK4/6 inhibitor. The primary endpoint is the 6-month PFS rate. Treatment will continue until disease progression or intolerable toxicity, with periodic imaging assessments and survival follow-up.

This description comes directly from the study's public registry record.

Talk to the study team

Fei Xu, MD  ·  +86-13711277870  ·  xufei@sysucc.org.cn

Kuikui Jiang, MD  ·  +86-15210589011  ·  jiangkk@sysucc.org.cn

Always discuss trial participation with your own doctor first.

Locations (1)

Sun Yat-sen University Cancer CenterGuangzhou, Guangdong, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07258108