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Study identifier: NCT07257510 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Pomalidomide Plus Orelabrutinib and Zuberitamab in Untreated Mantle Cell Lymphoma

Condition: Mantle Cell Lymphoma (MCL) · POZ  ·  Sponsor: Peking University Third Hospital

PhaseNA
Planned participants34
Who can joinAll sexes, 18 Years to 80 Years
Healthy volunteersNo

About this study

This multicenter trial evaluates the efficacy and safety of pomalidomide combined with orelabrutinib and zuberitamab (POZ) in patients with mantle cell lymphoma (MCL). After six cycles of POZ, patients who achieved minimal residual disease (MRD) negativity received maintenance therapy with orelabrutinib plus zuberitamab for up to 18 cycles. Those with MRD positivity were excluded and received alternative treatments. The primary endpoint is the MRD rate after six cycles of POZ. Secondary endpoints include progression-free survival (PFS), overall survival (OS), MRD rate, objective response rate (ORR), and safety.

This description comes directly from the study's public registry record.

Talk to the study team

Hongmei Jing  ·  86 010-82266781  ·  hongmei_jing@163.com

Always discuss trial participation with your own doctor first.

Locations (1)

Peking University Third HospitalBeijing, Beijing Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07257510