Condition: Scleroderma · Sponsor: Centre Hospitalier Universitaire Dijon
Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and/or maintaining the immune response and systemic inflammation. Our hypothesis is that fibroblasts play a predominant role in the genesis and maintenance of this pathology.
This description comes directly from the study's public registry record.
Bernard BONNOTTE · 03.80.29.34.32 · Bernard.bonnotte@chu-dijon.fr
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| CHU Dijon Bourgogne | Dijon, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07256418