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Study identifier: NCT07256210 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Feasibility and Safety of Donor-derived NK-cell Infusions for Leukemia Relapse Prophylaxis After Hematopoietic Stem Cell Transplantation

Condition: Acute Myeloid Leukemia · Acute Lymphoblastic T-cell Leukemia · Mixed Phenotype Acute Leukemia  ·  Sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology

PhasePhase 2
Planned participants15
Who can joinAll sexes, 1 Month to 25 Years
Healthy volunteersNo

About this study

This pilot clinical trial aims to evaluate the feasibility, adverse reactions and maximum tolerated dose of mbIL21 ex vivo-expanded donor-derived NK-cell infusions before and after haploidentical or matched-related hematopoietic stem cell transplantation in a cohort of pediatric and young adult patients with chemorefractory or minimal residual disease (MRD) positive acute leukemia.

This description comes directly from the study's public registry record.

Talk to the study team

Timofei Y Zavidnyi, MD  ·  +79153492188  ·  timofey.zavidnyy@dgoi.ru

Always discuss trial participation with your own doctor first.

Locations (1)

Dmitry Rogachev Federal Research and Clinical Centre of Paediatric Haematology, Oncology and ImmunologyMoscow, RussiaRecruiting

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Source record: clinicaltrials.gov/study/NCT07256210