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Study identifier: NCT07255300 Synced from ClinicalTrials.gov · July 28, 2026
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Follow up Study of Varapodio Trial: Effect of Longevity and Fasting Mimicking Diet on Risk Factors Age Correlated and Biomarkers of Aging

Condition: Fat Mass · Risk Factors Cardiovascular Disease · Epigenetic Aging  ·  Sponsor: Fondazione Valter Longo

PhaseNA
Planned participants135
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersYes

About this study

A large ongoing randomized, open-label trial aimed at evaluating the effects of two different dietary interventions, FMD and LD, on body composition and cardiovascular (CV) biomarkers in a real word population (NCT05698654) is actually ongoing. This trial started in January 2024 will enrol 501 adult subjects between the ages of 30 and 65: 167 subjects randomized to the FMD arm with a 5-day meal program once every three months for a 6-month period (arm 1); 167 subjects randomized to follow the FMD plus a Longevity Diet program (FMD+LD) for a 6-month period (arm 2); 167 randomized to the control group (arm 3) that will continue their usual diet. On 2024,410, participants were enrolled and randomly assigned to FMD, FMD + LD, or control arm. Although preliminary data demonstrated the beneficial effects of such nutritional plans on body weight, BMI, body composition, and cardiovascular (CV) biomarkers, limited data is available on the long-term effects of these powerful nutritional interventions.

This description comes directly from the study's public registry record.

Talk to the study team

Romina Inés Cervigni  ·  +390225138307  ·  rcervigni@fondazionevalterlongo.org

Alberto Montesanto  ·  +3930984492901  ·  alberto.montesanto@unical.it

Always discuss trial participation with your own doctor first.

Locations (1)

Ambulatorio Medico presso Biblioteca ComunaleVarapodio, Calabria, Italy, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT07255300