Condition: Menopausal Osteoporosis · Bone Markers · Sponsor: Martin Blomberg Jensen
During menopause, estrogen levels drop while the level of another hormone - LH (luteinizing hormone) substantially increases. This hormonal shift is linked to bone Loss and other complications. Estrogen therapy can help, but some women avoid it due to the increased risk of blood clots and cancer. This project will investigate whether blocking LH could offer a safe alternative to alleviate symptoms and complications of menopause since it is known from previous research that high LH levels contribute to both bone deterioration and metabolic issues. The goal is to explore new treatment options that can improve health and quality of life for women both during and after menopause. This randomized clinical trial is a single center, sponsor-investigator-initiated single-blinded 8 weeks clinical trial with four parallel groups comparing the effect of an gonadotropin releasing hormone(GnRH)-analog with placebo, and with two additional arms given estrogen or testosterone on change on bone health in postmenopausal women with moderate-to-severe symptoms.
This description comes directly from the study's public registry record.
Martin Blomberg Jensen, D.M.Sc · +45 38 68 63 64 · martin.blomberg.jensen@regionh.dk
Nadia Poulsen, MD · +45 38 68 63 64 · nadia.nicholine.poulsen.02@regionh.dk
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| Division of Translational Endocrinology, Department of Endocrinology and Internal Medicine, Copenhagen University Hospital Herlev. | Herlev, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07254429