Condition: Liver Cirrhosis · Gastroesophageal Varices Bleeding · Sponsor: Air Force Military Medical University, China
Transjugular intrahepatic portosystemic shunt (TIPS) is a key therapeutic intervention for complications of portal hypertension. However, the risk of post-procedural hepatic encephalopathy (HE) limits its broader clinical application. In the management of gastroesophageal variceal bleeding, the primary goal of TIPS is to reduce the portosystemic pressure gradient (PPG) to less than 12 mmHg (16 cmH₂O), which defines the standard TIPS procedure. The investigators hypothesize that, in patients undergoing TIPS for the prevention of variceal rebleeding, stent underdilation using a 6-mm balloon (underdilated TIPS) will not increase the risk of rebleeding but may reduce the incidence of overt HE and attenuate liver injury. To test this hypothesis, the investigators have designed a prospective, multicenter, randomized controlled trial.
This description comes directly from the study's public registry record.
Jun Tie, M.D.,Ph.D. · +862984771537 · tiejun7776@163.com
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| Fourth Military Medical University | Xi'an, Shaanxi, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07253389