Condition: Resectable Stage II-III Non-Small Cell Lung Cancer (NSCLC) · Sponsor: Hunan Province Tumor Hospital
This prospective study aims to investigate whether the time of day when immune checkpoint inhibitors (ICIs) are administered affects the efficacy of neoadjuvant immunotherapy in patients with resectable stage II-III non-small cell lung cancer (NSCLC). Eligible patients will receive standard-of-care neoadjuvant ICI plus platinum-based chemotherapy and be randomly assigned to either a morning infusion group (08:00-11:00) or an afternoon infusion group (15:00-18:00). The primary objective is to compare the pathological complete response (pCR) rates between groups. Secondary outcomes include major pathological response (MPR) and event-free survival (EFS). The study will include independent imaging and pathology review for endpoint assessment.
This description comes directly from the study's public registry record.
Yongchang Zhang, professor · +0086 13873123436 · zhanglei1152@126.com
Always discuss trial participation with your own doctor first.
| Hunna Cancer Hospital, Clinical Trails Center | Changsha, Hunan, China | Recruiting |
| Hunan Cancer hospital | Changsha, Hunan, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07251582