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Study identifier: NCT07250893 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression

Condition: Depression - Major Depressive Disorder · Childhood Traumas  ·  Sponsor: St. Joseph's Healthcare Hamilton

PhaseNA
Planned participants50
Who can joinFemale, 18 Years to 65 Years
Healthy volunteersNo

About this study

The RESPOND trial explores the link between early life adversity and later life depressive symptoms. The investigators have designed a new psychological therapy tailored to address the symptoms that can be caused by difficult experiences in early life. These symptoms include low mood, emotional dysregulation, and distressing thoughts and beliefs related to difficult or traumatic experiences. The investigators would like to see if this new therapy helps people feel better. The investigators are also studying the biological changes that can occur as a result of early life adversity, and how this therapy may influence those changes. To do this, the investigators ask questions about participants' physical and mental health and take blood samples.

This description comes directly from the study's public registry record.

Talk to the study team

Katerina Dikaios, MSc  ·  905 522 1155  ·  dikaiosk@mcmaster.ca

Always discuss trial participation with your own doctor first.

Locations (1)

St. Joseph's Healthcare HamiltonHamilton, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT07250893