Condition: the Effect of Instrumentation Kinematics on Intraoperative and Post-operative Pain · Sponsor: Al-Azhar University
Post-endodontic pain refers to the discomfort experienced following endodontic procedures. The incidence of post-operative pain is reported to be 25-40% regardless of the pulp and periradicular condition. It has been shown that pain prevalence declined from 40% in the first 48 h after treatment to 11% 7 days post-treatment. The mechanisms behind post-endodontic pain are complex and multifactorial that include host-dependent factors such as host immunity and preoperative pain history as well as operator-related factors such as chemical, mechanical or bacterial injury that occurs during endodontic procedure. A major contributor to this pain is the extrusion of infected debris as dentin chips, microorganisms, and the remnants of pulp tissue to the periradicular area. The intensity of pain is directly proportional to the extent of tissue injury caused. During root canal preparation, a variety of materials including dentin debris, pulp remnants, microorganisms, endotoxins, and irrigating solutions may be extruded into the periapical tissues, potentially leading to inflammation, increased vascular permeability, oedema, nerve compression and postoperative pain. Studies suggest that apical extrusion is affected by file systems, file kinematics and instrumentation techniques used during root canal preparation . Rotary systems vary in the amount of debris they extrude due to variations in cross-sectional design, flute depth, cutting blade, kinematics, taper, file sequence, tip size a…
This description comes directly from the study's public registry record.
Sabah M. Sobhy, PHD · +201096529143 · sabamorad@yahoo.com
Sabah M. Sobhy, PHD · 01096529143 · sabamorad@yahoo.com
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| from the outpatient clinic of Endodontic Department, Faculty of Dental Medicine for Girls, Al-Azhar University | Cairo, Egypt | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07250399