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Study identifier: NCT07249840 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Ropeginterferon for High Risk JAK2 Clonal Hematopoiesis

Condition: JAK2 Mutation  ·  Sponsor: Brigham and Women's Hospital

PhasePhase 1
Planned participants12
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if the drug ropeginterferon alfa-2b can be used safely to treat patients with a JAK2 mutation and high risk features, but do not yet have a myeloproliferative neoplasm. The main questions it aims to answer are: * Can we enroll 12 patients with JAK2 mutations and high risk features without a myeloproliferative neoplasm on a clinical trial evaluating the drug ropeginterferon? * Is ropeginterferon safe to use in these patients? Participants will: * Receive ropeginterferon as an injection under the skin once every 4 weeks * Visit the clinic every 1-3 months for checkups and tests

This description comes directly from the study's public registry record.

Talk to the study team

Chi-Joan How  ·  617-732-5190  ·  jhow@bwh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Mass General BrighamBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07249840