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Study identifier: NCT07249216 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Identification of Molecular Signals in Vitreous Humor Associated With Suboptimal Response to Vascular Endothelial Growth Factor (VEGF) Inhibition in Neovascular Age-related Macular Degeneration (nAMD) Within a Clinical Trial Setting

Condition: Age Related Macular Degeneration  ·  Sponsor: Singapore National Eye Centre

PhaseNA
Planned participants117
Who can joinAll sexes, 50 Years to no upper limit
Healthy volunteersNo

About this study

Neovascular age-related macular degeneration (nAMD), also called wet AMD, can cause serious vision loss. While anti-VEGF (anti Vascular Endothelial Growth Factor) treatments such as ranibizumab help many patients, about 20 40% have a suboptimal response. In this study, the investigators want to identify other factors (beyond VEGF) that might be driving the disease in these non-responding patients. By looking at samples from inside the eye (vitreous humor) and comparing "good responders" to "suboptimal responders", the investigators hope to find potential new treatment approaches or biomarkers for nAMD.

This description comes directly from the study's public registry record.

Talk to the study team

Gemmy Cheung  ·  63227460  ·  gemmy.cheung.c.m@singhealth.com.sg

Always discuss trial participation with your own doctor first.

Locations (1)

Singapore National Eye Centre/Singapore Eye Research InstituteSingapore, SingaporeRecruiting

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Source record: clinicaltrials.gov/study/NCT07249216