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Study identifier: NCT07248228 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)

Condition: Brain Metastases  ·  Sponsor: Case Comprehensive Cancer Center

PhasePhase 2
Planned participants90
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Participants in this research study have cancer that has spread to their brain, called brain metastases. One treatment for this type of cancer is called whole brain radiotherapy that stays away from a specific neurocognitive substructure, called the hippocampus, combined with medication to preserve cognitive function. This study compares that approach to another approach of whole brain radiotherapy that stays away from additional structures that are thought to have a role in cognitive function. Researchers want to see if there is a difference in the preservation of cognitive function between these two approaches.

This description comes directly from the study's public registry record.

Talk to the study team

Haley Perlow, MD  ·  (216) 286-3906  ·  haley.perlow@uhhospitals.org

Always discuss trial participation with your own doctor first.

Locations (1)

University Hospitals Seidman Cancer Center, Case Comprehensive Cancer CenterCleveland, Ohio, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07248228