Condition: Sickle Cell Disease · Glomerular Hyperfiltration · Sickle Cell Nephropathy · Sponsor: University Hospital, Tours
Background: Sickle cell disease is a genetic disorder of haemoglobin (which carries oxygen in red blood cells). The shape of sickle cell-patients' red blood cells is abnormal. Thus, red blood cells can be blocked in small vessels, responsible for painful crises due to a lack of downstream circulation. These crisis (acute vaso-occlusive crisis) require strong treatment based on morphine, and often require intensive care.However, treatment is often insufficiently effective. Patient can also experiment acute chest syndrome, a complication of vaso-occlusive crisis, which can be responsible for respiratory failure. In addition, patients with sickle cell disease frequently have kidney damage called sickle cell nephropathy, which in the early stages of the disease is responsible for renal hyperfiltration, meaning that the kidneys filter the blood more than necessary, with faster elimination of drugs. For example, it is known that higher doses of antibiotics must be used in these patients than in the general population for the same effectiveness. The hypothesis of the study is that morphine, a drug eliminated by kidneys, is underdosed in patients with sickle cell disease, which is responsible for the difficulties in achieving sufficient analgesia. Objective: To determine the glomerular filtration rate threshold for which it is necessary to prescribe higher doses of morphine in sickle cell patients with vaso-occlusive crisis. Methods: inclusion of 100 patients admitted to intensive …
This description comes directly from the study's public registry record.
Charlotte SALMON-GANDONNIERE, MD · +33 2 47 47 38 55 · charlotte.salmon.gandonniere@gmail.com
Coralie TAILLEBUIS · +332 47 47 39 09 · cpcq@chu-tours.fr
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| CHRU de Tours | Tours, France, France | Recruiting |
| Henri-Mondor | Créteil, France | Not Yet Recruiting |
| CH Le Mans | Le Mans, France | Not Yet Recruiting |
| CHU de Nantes | Nantes, France | Not Yet Recruiting |
| CHU d'Orléans | Orléans, France | Not Yet Recruiting |
| CHU de Rennes | Rennes, France | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07246265