Condition: Ventilator Acquired Pneumonia · Mechanical Ventilation Complication · Sponsor: Region Skane
Ventilator-associated pneumonia (VAP) is a common and serious infection in patients receiving mechanical ventilation in intensive care units. Current diagnostic methods are imprecise, leading to unnecessary antibiotic use and delayed treatment. The ClusterVAP study aims to identify biologically and clinically distinct subgroups of patients with suspected VAP by analyzing proteins in bronchoalveolar lavage (BAL) fluid using advanced proteomic techniques. This multicentre observational study will enroll approximately 400 adult patients from intensive care units in Sweden, France, Portugal, Denmark, and the United Kingdom. BAL or mini-BAL samples collected for clinical reasons will be analyzed to define "pneumoclusters" and explore their association with patient outcomes. The study will also identify candidate biomarkers that could support future diagnostic tools. No experimental treatments are given; all patients receive standard care. Results may improve diagnostic accuracy and guide personalized treatment strategies for critically ill patients.
This description comes directly from the study's public registry record.
Magnus Paulsson, MD PhD · +46703124424 · magnus.paulsson@med.lu.se
Always discuss trial participation with your own doctor first.
| CHU Limoges | Limoges, France | Not Yet Recruiting |
| Hospital de São Francisco Xavier | Lisbon, Portugal | Not Yet Recruiting |
| Skånes universitetssjukhus | Lund, Sweden | Recruiting |
| Karolinska universitetssjukhuset | Stockholm, Sweden | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07245888