Condition: Dental Caries · Streptococcus Mutans · Tooth Demineralization · Sponsor: Cardenal Herrera University
Background This study is part of a doctoral research project at Universidad Cardenal Herrera CEU (Spain), directed by Prof. Santiago Arias de Luxán and conducted by doctoral candidate Shirli Kelmendi within the PhD program in Translational Medicine. Fixed orthodontic appliances complicate oral hygiene by creating retention areas that favor bacterial colonization and alter microbial balance. These conditions increase plaque accumulation and Streptococcus mutans (S. mutans) proliferation in saliva and plaque. The frequent low-pH environment favors aciduric bacteria such as S. mutans and lactobacilli, promoting enamel demineralization and formation of white spot lesions (WSLs) or cavitations. WSLs appear as opaque white areas due to subsurface mineral loss, mainly in the gingival third of the crown. They may develop as early as one month after bracket placement, while in patients without appliances, progression occurs after at least six months. Increased S. mutans levels have been reported as early as six weeks after treatment start. Risk factors include poor brushing, lack of floss or rinse use, time since last cleaning, and presence of caries or lesions. Intervention MI Paste Plus (GC, Japan) is a remineralizing cream with 0.20% sodium fluoride (900 ppm) and 10% CPP-ACP (RECALDENT™), providing calcium and phosphate stabilized by casein phosphopeptides. It has antibacterial and remineralizing effects, suitable during or after orthodontic treatment to prevent or reduce WSLs. …
This description comes directly from the study's public registry record.
Santiago Arias de Luxán, DMD, PhD · +34 961 369 000 · santiago.arias@uchceu.es
Shirli Kelmendi, DMD · +355697721263 · shirli.kelmendi@alumnos.uchceu.es
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| Beaty Dent | Tirana, Albania, Albania | Recruiting |
| Happy Dent | Tirana, Albania, Albania | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07244991