Condition: Colorectal Cancer (Diagnosis) · Colorectal Cancer Metastatic · Colorectal Cancer (CRC) · Sponsor: Anbogen Therapeutics, Inc.
The goal of this clinical trial is to evaluate the safety and tolerability of escalating doses of ABT-301 in combination with fixed doses of tislelizumab 200 mg IV infusion and bevacizumab 7.5 mg/kg IV infusion Q3W, in participants with pMMR/non-MSI-H colorectal cancer (CRC). It will also determine the maximum tolerated dose (MTD) and select the recommended Phase 2 dose (RP2D) of ABT-301. Participants will receive ABT-301 administered once daily (QD ±3 hours) or twice daily (Q12H ±3 hours, at least 9 hours apart) with water in 21-day treatment cycles. Tislelizumab 200 mg IV and bevacizumab 7.5 mg/kg IV Q3W will be given in both parts of the study.
This description comes directly from the study's public registry record.
Ryan Hua · +886-2-8979-8616 · abt301-103@anbogen.com
Always discuss trial participation with your own doctor first.
| Liverpool Cancer Therapy Centre | Liverpool, New South Wales, Australia | Not Yet Recruiting |
| Macquarie University Hospital (MUH) | Macquarie Park, New South Wales, Australia | Not Yet Recruiting |
| Scientia Clinical Research | Randwick, New South Wales, Australia | Recruiting |
| Greenslopes Private Hospital - Cyril Gilbert Cancer Centre | Greenslopes, Queensland, Australia | Not Yet Recruiting |
| The Queen Elizabeth Hospital (TQEH) | Woodville South, South Australia, Australia | Not Yet Recruiting |
| Monash University - Faculty of Medicine, Nursing and Health Sciences | Clayton, Victoria, Australia | Not Yet Recruiting |
| Austin Health - Cancer Clinical Trials Centre (CCTC) | Heidelberg, Victoria, Australia | Not Yet Recruiting |
| Linear Clinical Research | Nedlands, Western Australia, Australia | Not Yet Recruiting |
| Kaohsiung Medical University Chung-Ho Memorial Hospital | Kaohsiung City, Taiwan | Not Yet Recruiting |
| E-Da Cancer Hospital | Kaohsiung City, Taiwan | Not Yet Recruiting |
| Chang Gung Medical Foundation, Kaohsiung Chang Gung Memorial Hospital | Kaohsiung City, Taiwan | Not Yet Recruiting |
| Taipei Medical University Shuang Ho Hospital, Ministry of Health and Welfare | New Taipei City, Taiwan | Not Yet Recruiting |
+ 3 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07244705