Condition: Hematopoietic Stem Cell Transplantation · Graft Failure · Sponsor: Children's Hospital Medical Center, Cincinnati
The investigators hypothesize that graft rejection after hematopoietic stem cell transplant (HSCT) is primarily driven by interferon gamma, and prophylactic interferon gamma inhibition in high-risk patients will prevent graft rejection. Additionally, knowledge of emapalumab PK/PD and in vitro mechanistic effects of emapalumab in this novel setting will guide optimization of dosing regimens and treatment approaches in future studies.
This description comes directly from the study's public registry record.
Jessica Anderson, BSN, RN, CCRC · 513-636-4200 · Jessica.Anderson@cchmc.org
Manisha Pathak, MS · 513-636-4200 · Manisha.Pathak@cchmc.org
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| Cincinnati Children's Hospital Medical Center | Cincinnati, Ohio, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07244419