Condition: Medulloblastoma Recurrent · Medulloblastoma, Childhood, Recurrent · Medulloblastoma, SHH-activated and TP53 Mutant · Sponsor: Mohammad H. Abu Arja
The purpose of this study is to create a biobank for patients diagnosed with Sonic Hedgehog Medulloblastoma at Baylor College of Medicine/Texas Children's Cancer Center. A biobank is a facility that stores and manages biological samples (such as blood, tissue, or DNA) from individuals, along with detailed health information, for use in medical research to study diseases and develop new treatments. The investigators are requesting participants' permission to add their information and samples to this biobank. Being in this research study is voluntary; it is the participant's choice. If the participant joins this study, they can still stop at any time. If the participant decides to participate, the investigators will review the participant's clinical medical records, demographics, treatment history, family history, and imaging. The investigators will also collect biological samples from the participant and the biological parents' buccal swabs (optional). The participation in this biobank will last about 5 years from the decision to participate. Why am I being asked to participate? The participant or their child is invited to participate in this study if the participant or their tumor may have a U1 mutation. U1 mutation is associated with an error in the gene that splices the tumor DNA, leading to random splicing that may increase the tumor mutation burden and generate novel tumor neoantigens (targets). Studying the U1 mutation will enable the investigator to design more effe…
This description comes directly from the study's public registry record.
Mohammad H Abu-Arja, MD, MSc · 832-824-0592 · mohammad.abuarja@bcm.edu
Ta Tara Rideau · TLRIDEAU@texaschildrens.org
Always discuss trial participation with your own doctor first.
| Baylor College of Medicine | Houston, Texas, United States | Recruiting |
| MD Anderson Cancer Center | Houston, Texas, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07242963