Condition: SCHIZOPHRENIA 1 (Disorder) · Schizotypal Disorder · Post Traumatic Stress Symptoms · Sponsor: Nikolai Albert
Overview: People with psychotic disorders frequently have a history of traumatic events such as neglect, bullying, or physical and sexual abuse. Many experience significant symptoms of post-traumatic stress, but trauma-focused treatment is rarely offered in standard psychiatric care. This pilot study investigates whether two established trauma therapies can be delivered safely and acceptably to young adults with psychotic disorders receiving care in the OPUS early-intervention program. Objectives: The main aim is to evaluate the feasibility and acceptability of two trauma-focused treatments-Prolonged Exposure (PE) and Eye Movement Desensitization and Reprocessing (EMDR)-in patients with psychotic disorders and post-traumatic stress symptoms. The study is not designed to test treatment efficacy but to determine whether a larger randomized controlled trial is practical. Study Design: This is a pilot and feasibility study. Twenty OPUS patients with a diagnosis within the schizophrenia spectrum and clinically relevant PTSD symptoms will be randomly assigned to either PE or EMDR. All participants continue their usual OPUS care while attending weekly trauma-focused therapy sessions. Assessments: At baseline and follow-up, participants complete clinical interviews and questionnaires assessing trauma symptoms, psychotic symptoms, functioning, well-being, recovery experiences, and possible negative effects. Instruments include the PCL-5, CAPS-5, Mini-TALE, PANSS-6, PSP, WHO-5, …
This description comes directly from the study's public registry record.
Nikolai Albert, MD, PhD · +45 29925014 · nikolai.albert@regionh.dk
Rikke Hilker, MD, PhD · +45 25775745 · rikke.hilker@regionh.dk
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| Mental Health Centre Copenhagen | Copenhagen, Denmark, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07242586