Condition: Autoimmune Rheumatic Diseases · Sponsor: University of Sao Paulo General Hospital
This clinical trial aims to evaluate the effect of temporary methotrexate (MTX) discontinuation on the humoral immunogenicity of the 20-valent pneumococcal conjugate vaccine (PCV20) in adult patients with autoimmune rheumatic diseases (ARDs). Key questions: * Does suspending MTX for 2 weeks after PCV20 enhance humoral immunogenicity? * What is the impact of MTX discontinuation on functional opsonophagocytic activity (OPA) and cellular immunity? * What is the risk of disease flaring with MTX withdrawal?
This description comes directly from the study's public registry record.
Clovis A Silva, Full Professor · (11) 2661-6105 · vacina.reumatousp@gmail.com
Always discuss trial participation with your own doctor first.
| Reumatology division of Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo | São Paulo, São Paulo, Brazil | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07242092