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Study identifier: NCT07240766 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

HRS-4642 in Combination With Nimotuzumab and Chemotherapy for BRPC With KRAS G12D Mutation

Condition: Borderline Resectable Pancreatic Adenocarcinoma  ·  Sponsor: Zhejiang University

PhasePhase 2
Planned participants40
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This study is a Phase II clinical trial that plans to enroll 40 patients with borderline resectable pancreatic cancer harboring a KRAS G12D mutation, aiming to evaluate the efficacy of HRS-4642 in combination with Nimotuzumab and AG in borderline resectable pancreatic cancer. The study process includes a screening period (from the signing of the informed consent form until the first dose), a treatment period (from the first dose to the discontinuation of study treatment), and a follow-up period (safety follow-up and survival follow-up after the discontinuation of study treatment).

This description comes directly from the study's public registry record.

Talk to the study team

Tingbo Liang, MD  ·  86+19941463683  ·  liangtingbo@zju.edu.cn

Yiwen Chen, MD  ·  86+15088682641  ·  yiwenchen0705@126.com

Always discuss trial participation with your own doctor first.

Locations (2)

First Affiliated Hospital of Zhejiang University Schlool of MedicineHangzhou, Zhejiang, ChinaNot Yet Recruiting
the First Affiliated Hospital of Zhejiang University, School of MedicineHangzhou, Zhejiang, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07240766