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Study identifier: NCT07237594 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

IL-17 Blockade to Decrease irAEs (REPLAY)

Condition: Metastatic Melanoma  ·  Sponsor: Duke University

PhasePhase 1
Planned participants4
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The primary objective of this study is to determine the safety and feasibility of administering an IL-17A (human IgG1κ) monoclonal antibody, (Secukinumab, Cosentyx®) to participants with metastatic melanoma who have previously received immune checkpoint inhibitor (ICI) therapy, experienced an immune related adverse event (colitis, hepatitis, skin rash, psoriatic arthritis) to ICI, and are re-initiating ICI therapy.

This description comes directly from the study's public registry record.

Talk to the study team

April Salama, MD  ·  +1 919 681 9507  ·  april.salama@duke.edu

Emily Bolch  ·  emily.bolch@duke.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Duke University Health SystemDurham, North Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07237594