Condition: Febrile Urinary Tract Infection · Sponsor: Uppsala University
The goal of this clinical trial is to learn if oral treatment with pivmecillinam is effective to treat febrile urinary tract infections in adult patients. Hospitalized patients who have received 2-4 days of intravenous antibiotic therapy for febrile urinary tract infections, and have responded to treatment, will be randomized to either pivmecillinam or standard treatment (other oral or intravenous antibiotics). The main question the study aims to answer is if oral follow-up with pivmecillinam is as effective as standard treatment. Patients will be evaluated for clinical response (resolution of fever and urinary tract symptoms) and microbiological response (no growth of bacteria in urine) 7 and 28 days after the end of treatment. Patients will also be asked about side effects. Some of the participants will also be examined for changes in the gut microbiome and drug exposures in blood and urine. Participants will: 1. Keep a patient diary to record antibiotic intake, body temperature, urinary tract symptoms, and suspected side effects until 7 days after end of treatment. 2. Participate in phone interviews 7 and 28 days after end of treatment to assess clinical response. 3. Provide urine samples 7 and 28 days after end of treatment to evaluate microbiological response. 4. A subgroup (60 patients) will provide fecal samples at five time-points over three months to assess antibiotic-induced changes in the gut microbiome. 5. A subgroup (30 patients) treated with to pivmecillinam …
This description comes directly from the study's public registry record.
Thomas Tängdén, MD, Professor · +46 708 370323 · thomas.tangden@medsci.uu.se
Lisa Faxén, MD, PhD student · +46 768 721806 · lisa.faxen@medsci.uu.se
Always discuss trial participation with your own doctor first.
| Haukeland University Hospital | Haukeland, Norway | Not Yet Recruiting |
| Oslo University Hospital | Oslo, Norway | Not Yet Recruiting |
| Södra Älvsborg Hospital | Borås, Sweden | Not Yet Recruiting |
| Eskilstuna Hospital | Eskilstuna, Sweden | Not Yet Recruiting |
| Sahlgrenska University Hospital | Gothenburg, Sweden | Recruiting |
| Blekinge Hospital | Karlskrona, Sweden | Not Yet Recruiting |
| Skåne University Hospital | Lund, Sweden | Not Yet Recruiting |
| Örebro University Hospital | Örebro, Sweden | Recruiting |
| Karolinska University Hospital | Stockholm, Sweden | Not Yet Recruiting |
| Sundsvall Hospital | Sundsvall, Sweden | Not Yet Recruiting |
| Umeå University Hospital | Umeå, Sweden | Not Yet Recruiting |
| Uppsala University Hospital | Uppsala, Sweden | Recruiting |
+ 1 more locations — full list on the registry record.
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT07236944