Condition: Recurrent Pregnancy Loss(RPL) · Anxiety · Sponsor: Shenyang Medical College
The goal of this clinical trial is to determine whether high-intensity, low-frequency periodic repetitive transcranial magnetic stimulation (rTMS) applied to the right dorsolateral prefrontal cortex (DLPFC) can modulate cardiac autonomic regulation in women with recurrent pregnancy loss (RPL) and comorbid anxiety. The main questions it aims to answer are: Does 120% resting motor threshold (RMT) rhythmic low-frequency rTMS reduce heart rate during stimulation time windows compared with sham stimulation? Does 120% RMT rTMS alter heart-rate-variability (HRV) spectral power at the target frequency (0.0167 Hz) compared with sham stimulation? Researchers will compare active rTMS with sham rTMS to determine whether the active intervention produces measurable changes in cardiac autonomic activity. Participants will: Undergo a single session of rTMS or sham stimulation consisting of 20 consecutive stimulation time windows (each 60 seconds: 40 seconds of 1-Hz stimulation plus 20 seconds of rest) targeting the right DLPFC; Have continuous electrocardiography (ECG) recordings collected during the entire stimulation session; Complete clinical and psychiatric assessments before participation.
This description comes directly from the study's public registry record.
Fei Meng, MD · 86-024-85715635 · mengfei665@sohu.com
Lin Tao, MM · 86-18802401698 · 1939908868@qq.com
Always discuss trial participation with your own doctor first.
| The Second Affiliated Hospital of Shenyang Medical College | Shenyang, Liaoning, China | Recruiting |
| Central Hospital Affiliated to Shenyang Medical College | Shenyang, Liaoning, China | Recruiting |
| 242 Hospital Affiliated to Shenyang Medical College | Shenyang, Liaoning, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07233278