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Study identifier: NCT07232602 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

KEYMAKER-U04 Substudy 04D: A Clinical Study of New Treatments Given With Enfortumab Vedotin and Pembrolizumab in People With Urothelial Cancer (MK-3475-04D/KEYMAKER-U04)

Condition: Bladder Cancer  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 1/Phase 2
Planned participants55
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Researchers are looking for new ways to treat people with urothelial cancer (UC) that is locally advanced or metastatic. The standard treatment for locally advanced or metastatic UC is enfortumab vedotin (EV) given with pembrolizumab. The goals of this study are to learn about: * The safety of the study treatment when given with standard treatment and if people tolerate it * The number of people who have the cancer respond (cancer gets smaller or goes away) with the new study treatment when given with standard treatment.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (16)

UCSF Medical Center at Mission Bay ( Site 5044)San Francisco, California, United StatesRecruiting
University of Chicago Medical Center ( Site 5037)Chicago, Illinois, United StatesRecruiting
Cleveland Clinic Taussig Cancer ( Site 5036)Cleveland, Ohio, United StatesRecruiting
Huntsman Cancer Institute ( Site 5041)Salt Lake City, Utah, United StatesRecruiting
FALP ( Site 5151)Santiago, Region M. de Santiago, ChileRecruiting
CHU de Bordeaux Hop St ANDRE ( Site 5607)Bordeaux, Gironde, FranceRecruiting
Rambam Health Care Campus ( Site 5501)Haifa, IsraelRecruiting
Rabin Medical Center ( Site 5504)Petah Tikva, IsraelRecruiting
Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL) ( Site 5302)Amsterdam, North Holland, NetherlandsRecruiting
Erasmus MC ( Site 5303)Rotterdam, South Holland, NetherlandsRecruiting
Severance Hospital, Yonsei University Health System ( Site 5903)Seoul, South KoreaRecruiting
Asan Medical Center ( Site 5901)Seoul, South KoreaRecruiting

+ 4 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07232602