Condition: Postoperative Pain Management · Laparoscopic Hysterectomy · Postoperative Recovery · Sponsor: Ataturk University
This study aims to compare the effects of intrathecal morphine with trocar-site infiltration and intraperitoneal bupivacaine on postoperative pain control, quality of recovery, and inflammatory response in patients undergoing elective laparoscopic hysterectomy. Laparoscopic hysterectomy is widely used for benign gynecologic conditions, but postoperative pain may result from trocar-site trauma, peritoneal irritation, and carbon dioxide insufflation. Effective postoperative analgesia can improve patient comfort, reduce opioid use, and enhance early recovery. Intrathecal morphine is known to provide potent early postoperative analgesia but may cause side effects such as nausea, vomiting, pruritus, and respiratory depression. Local anesthetic techniques, including trocar-site infiltration and intraperitoneal bupivacaine, have also been shown to reduce postoperative pain after minimally invasive gynecologic surgery. In this prospective, randomized, double-blind study, patients will be assigned to one of two groups: Intrathecal morphine (ITM) administered before induction of anesthesia; Local anesthesia group (LA) receiving trocar-site infiltration and intraperitoneal bupivacaine at the end of surgery. The primary outcome is the Quality of Recovery-15 (QoR-15) score at 24 hours. Secondary outcomes include pain scores, opioid consumption, time to first rescue analgesia, postoperative nausea and vomiting, pruritus, respiratory depression, early mobilization, bowel function recov…
This description comes directly from the study's public registry record.
Ayşenur Dostbil, Associate Professor · +90-533-367-66-96 · adostbil@hotmail.com
Mehmet Akif Yılmaz, assistant doctor · +90-534-653-35-39 · mehmetakifyilmaz025@gmail.com
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| Ataturk University | Erzurum, Turkey (Türkiye) | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07232108