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Study identifier: NCT07231991 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Learn How the Body Processes the Study Medicine Called Vepdegestrant in People With Loss of Liver Function

Condition: Healthy Participants  ·  Sponsor: Pfizer

PhasePhase 1
Planned participants24
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersYes

About this study

The purpose of the study is to look at how the body processes a study medicine called vepdegestrant in participants with loss of liver function relative to people with normal liver function. This study is seeking participants who are: * females who cannot have children or males * between 18 and 70 years of age * weigh more than 50 Kilograms (110 pounds) * either healthy with normal liver function or have loss of liver function All participants in this study will take one dose of vepdegestrant by mouth. This study looks at how the medicine is changed and removed from the body after being taken by the participants. The amount of vepdegestrant in participants with loss of liver function will be compared to the amount of vepdegestrant in participants with normal liver function. All participants will stay at the study clinic for about 11 days and 10 nights.

This description comes directly from the study's public registry record.

Talk to the study team

Pfizer CT.gov Call Center  ·  1-800-718-1021  ·  ClinicalTrials.gov_Inquiries@pfizer.com

Always discuss trial participation with your own doctor first.

Locations (4)

Clinical Pharmacology of MiamiMiami, Florida, United StatesRecruiting
Floridian Clinical Research, LLCMiami Lakes, Florida, United StatesRecruiting
Orlando Clinical Research CenterOrlando, Florida, United StatesRecruiting
Genesis Clinical Research, LLCTampa, Florida, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07231991