Condition: Cancer · Opioid Induced Constipation (OIC) · Sponsor: Professor Monique A. H. Steegers
This study looks at how well a medicine called naldemedine works for people with cancer who become constipated while taking opioids. Opioids are medications prescribed to treat persistent or severe pain. Opioids can slow down the bowel and make it hard to pass stool. About 6 out of 10 people who use opioids have constipation. Laxatives such as lactulose or macrogol are described to help with this problem. If laxatives do not work, doctors may use special medicines called opioid blockers that act only in the gut. These medicines help relieve constipation without reducing pain relief. Naldemedine is one of these opioid blockers. It became available in the Netherlands in 2024 but is not yet widely used. The goal of this study is to learn how well naldemedine works in everyday care and how people feel while using it. Researchers will collect information on both medical results and participants' experiences.
This description comes directly from the study's public registry record.
Josje Evers, MD · +31650087799 · j.evers@amsterdamumc.nl
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| Amsterdam UMC | Amsterdam, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07231796