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Study identifier: NCT07229235 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

REAL-CARE: Real-world Effectiveness of Iptacopan in Italian Patients With Paroxysmal Nocturnal Hemoglobinuria

Condition: Paroxysmal Nocturnal Hemoglobinuria (PNH)  ·  Sponsor: Novartis Pharmaceuticals

PhaseN/A
Planned participants50
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study evaluates iptacopan effectiveness and safety in routine clinical practice, with a focus on hematological response, transfusion avoidance, and patient-reported outcomes. The primary objective of the REAL-CARE study is to is to assess the long-term hematological response following iptacopan initiation. This will be assessed through the absolute change in hemoglobin (Hb) levels at 12 months post-initiation, and the proportion of patients who remain free from red blood cell (RBC) transfusions, prescribed as per local requirement and based on Investigator's judgment, from Day 14 through Month 12 after starting iptacopan.

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  +41613241111  ·  novartis.email@novartis.com

Novartis Pharmaceuticals

Always discuss trial participation with your own doctor first.

Locations (12)

Novartis Investigative SiteAlessandria, AL, ItalyRecruiting
Novartis Investigative SiteAvellino, AV, ItalyRecruiting
Novartis Investigative SiteBrescia, BS, ItalyRecruiting
Novartis Investigative SiteFlorence, FI, ItalyRecruiting
Novartis Investigative SiteGenova, GE, ItalyRecruiting
Novartis Investigative SiteMilan, MI, ItalyRecruiting
Novartis Investigative SiteMilan, MI, ItalyRecruiting
Novartis Investigative SitePalermo, PA, ItalyRecruiting
Novartis Investigative SiteRoma, RM, ItalyRecruiting
Novartis Investigative SiteRoma, RM, ItalyRecruiting
Novartis Investigative SiteTorino, TO, ItalyRecruiting
Novartis Investigative SiteBassano del Grappa, VI, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT07229235