Condition: Locally Advanced Cutaneous Squamous Cell Carcinoma · Sponsor: Philogen S.p.A.
Open-label, single-arm, multicenter study in patients with locally advanced, histologically confirmed Cutaneous Squamous Cell Carcinoma (LacSCC) amenable to intratumoral injection, who have progressed on or are intolerant to Immune Checkpoint Inhibitor (ICI). The primary objective of the study is to evaluate the activity of intratumoral L19IL2/L19TNF, while the secondary objective is to assess the safety and efficacy. The patients will receive multiple intratumoral administrations of combined L19IL2 and L19TNF to all injectable cutaneous and subcutaneous lesions once weekly for up to 4 weeks: for those who have a partial response or stable disease as their best response, a second 4-week course L19IL2/L19TNF of four weekly injections may be administered as per treating physician judgement. Patients will be followed for a maximum of 160 weeks after beginning of treatment.
This description comes directly from the study's public registry record.
Lisa Nadal · +3905771526723 · lisa.nadal@philogen.com
Concetta Aulicino · +39057717816 · regulatory@philogen.com
Always discuss trial participation with your own doctor first.
| UC Irvine Health- Chao Family Comprehensive Cancer Center | Orange, California, United States | Recruiting |
| Winship Cancer Institute, Emory University | Atlanta, Georgia, United States | Recruiting |
| Dana-Farber Cancer Institute | Boston, Massachusetts, United States | Recruiting |
| Duke University Medical Center | Durham, North Carolina, United States | Recruiting |
| The Ohio State University Wexner Medical Center Clinical Laboratories | Columbus, Ohio, United States | Not Yet Recruiting |
| The University of Texas MD Anderson Cancer Center | Houston, Texas, United States | Recruiting |
| Universitaetsklinikum Augsburg | Augsburg, Germany | Recruiting |
| Charite Universitaetsmedizin Berlin KöR | Berlin, Germany | Recruiting |
| Universitaetsklinikum Essen AöR | Essen, Germany | Recruiting |
| Universitaetsklinikum Halle (Saale) AöR | Halle, Germany | Recruiting |
| Universitaetsklinikum Heidelberg AöR | Heidelberg, Germany | Recruiting |
| Universitaetsklinikum Schleswig-Holstein AöR | Kiel, Germany | Recruiting |
+ 7 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07228442