Condition: Locally Advanced Basal Cell Carcinoma · Sponsor: Philogen S.p.A.
Open-label, single-arm, multicentre study in patients with locally advanced BCC amenable to intratumoral injection, who have progressed on or are intolerant to systemic therapy as determined by a local multidisciplinary tumor board. The primary objective of the study is to evaluate the activity of intratumoral L19IL2/L19TNF, while the secondary objective is to assess the safety and efficacy. The patients will receive multiple intratumoral administrations of combined L19IL2 and L19TNF to all injectable cutaneous and subcutaneous lesions once weekly for up to 4 weeks: for those who have a partial response or stable disease as their best response, a second 4-week course L19IL2/L19TNF of four weekly injections may be administered as per treating physician judgement. Patients will be followed for a maximum of 160 weeks after beginning of treatment.
This description comes directly from the study's public registry record.
Lisa Nadal · +3905771526723 · lisa.nadal@philogen.com
Concetta Aulicino · +39057717816 · regulatory@philogen.com
Always discuss trial participation with your own doctor first.
| H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. | Tampa, Florida, United States | Recruiting |
| Winship Cancer Institute, Emory University | Atlanta, Georgia, United States | Recruiting |
| Memorial Sloan Kettering | New York, New York, United States | Not Yet Recruiting |
| The Ohio State University Wexner Medical Center Clinical Laboratories | Columbus, Ohio, United States | Not Yet Recruiting |
| The University of Texas MD Anderson Cancer Center | Houston, Texas, United States | Recruiting |
| Universitaetsklinikum Augsburg | Augsburg, Germany | Recruiting |
| Charite Universitaetsmedizin Berlin KöR | Berlin, Germany | Recruiting |
| Universitaetsklinikum Essen AöR | Essen, Germany | Recruiting |
| Universitaetsklinikum Halle (Saale) AöR | Halle, Germany | Recruiting |
| Heidelberg University | Heidelberg, Germany | Recruiting |
| Universitaetsklinikum Schleswig-Holstein AöR | Kiel, Germany | Recruiting |
| Universitaetsklinikum Tuebingen AöR | Tübingen, Germany | Recruiting |
+ 6 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07227870