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Study identifier: NCT07227636 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy

Condition: Colorectal Cancer · Rectal Cancer  ·  Sponsor: Memorial Sloan Kettering Cancer Center

PhasePhase 2
Planned participants284
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The researchers are doing this study to find out whether the combination of botensilimab and balstilimab (BOT/BAL), followed by balstilimab alone, is an effective treatment for people with microsatellite stable (MSS) colorectal cancer or colorectal liver metastases (CRLM) who have measurable residual disease (MRD) after standard treatment with surgery and chemotherapy or total neoadjuvant therapy (TNT).

This description comes directly from the study's public registry record.

Talk to the study team

Neil Segal, MD, PhD  ·  646-888-4187  ·  crc@mskcc.org

Luis Diaz, MD  ·  646-888-4641

Always discuss trial participation with your own doctor first.

Locations (7)

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking Ridge, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)Middletown, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Bergen (Limited Protocol Activities)Montvale, New Jersey, United StatesRecruiting
Memorial Sloan Kettering Commack (Limited Protocol Activities)Commack, New York, United StatesRecruiting
Memorial Sloan Kettering Westchester (All Protocol Activities)Harrison, New York, United StatesRecruiting
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New York, New York, United StatesRecruiting
Memorial Sloan Kettering Nassau (Limited Protocol Activities)Rockville Centre, New York, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07227636