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Study identifier: NCT07227454 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder

Condition: Depressive Disorder, Major  ·  Sponsor: Janssen Research & Development, LLC

PhasePhase 3
Planned participants258
Who can joinAll sexes, 12 Years to 17 Years
Healthy volunteersNo

About this study

The purpose of this study is to evaluate how well JNJ-54135419 works (efficacy) in addition to comprehensive standard of care (SoC) in rapidly reducing the symptoms of major depressive disorder (MDD, a mental disorder characterized by a persistent feeling of sadness and loss of interest in activities) as compared with psychoactive placebo (does not contain JNJ-54135419) plus SoC in adolescent participants with acute suicidal ideation or behavior.

This description comes directly from the study's public registry record.

Talk to the study team

Study Contact  ·  844-434-4210  ·  Participate-In-This-Study1@its.jnj.com

Always discuss trial participation with your own doctor first.

Locations (30)

University of Alabama at BirminghamBirmingham, Alabama, United StatesRecruiting
Peachford Hospital-Atlanta Behavioral ResearchAtlanta, Georgia, United StatesRecruiting
Endeavor Health Evanston HospitalEvanston, Illinois, United StatesRecruiting
University of CincinnatiCincinnati, Ohio, United StatesRecruiting
Bradley HospitalEast Providence, Rhode Island, United StatesRecruiting
John S Dunn Behavioral Sciences Center at UTHealth HoustonHouston, Texas, United StatesRecruiting
Sociedade Literaria e Caritativa Santo Agostinho Hospital Sao JoseCriciúma, BrazilRecruiting
Instituto ApiceSalvador, BrazilRecruiting
Centro Integrado FaciliSão Bernardo do Campo, BrazilRecruiting
Instituto de Pesquisa Pensi Sandra Mutarelli SetubalSão Paulo, BrazilRecruiting
Fundacao Faculdade de Medicina Hospital da Clinicas da Faculdade de Medicina de Sao PauloSão Paulo, BrazilRecruiting
Debreceni Egyetem Klinikai KozpontDebrecen, HungaryRecruiting

+ 18 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07227454