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Study identifier: NCT07227415 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

Condition: Carcinoma, Renal Cell · Advanced Renal Cell Carcinoma · Renal Cancer  ·  Sponsor: Pfizer

PhasePhase 1/Phase 2
Planned participants224
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is testing a new medicine called PF-08634404 and how it works in adults with advanced Renal Cell Carcinoma (RCC)- a type of kidney cancer that is either locally advanced (spread to nearby tissues) or metastatic (spread to other parts of the body). The study will look at the safety of the study medicine, when given alone or with other anticancer medicines, and how this type of cancer responds to them. To join the study, participants must be adults; with locally advanced or metastatic RCC; who have not received treatment for their advanced kidney cancer. Participants will receive study medicine either alone or with other anticancer medicines. The medicine will be given through intravenous (IV) infusions, which means it will be injected directly into a vein. All treatments will take place at clinical study sites, where trained medical staff will take care of participants during and after each visit.

This description comes directly from the study's public registry record.

Talk to the study team

Pfizer CT.gov Call Center  ·  1-800-718-1021  ·  ClinicalTrials.gov_Inquiries@pfizer.com

Always discuss trial participation with your own doctor first.

Locations (128)

Mayo Clinic Building- PhoenixPhoenix, Arizona, United StatesRecruiting
Mayo Clinic ArizonaScottsdale, Arizona, United StatesRecruiting
Highlands Oncology GroupFayetteville, Arkansas, United StatesRecruiting
Highlands Oncology GroupRogers, Arkansas, United StatesRecruiting
Highlands Oncology GroupSpringdale, Arkansas, United StatesRecruiting
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)Duarte, California, United StatesRecruiting
City of Hope Investigational Drug Services (IDS)Duarte, California, United StatesRecruiting
UC San Diego Medical Center - EncinitasEncinitas, California, United StatesNot Yet Recruiting
City of Hope Investigational Drug Services (IDS)Irvine, California, United StatesRecruiting
City of HopeIrvine, California, United StatesRecruiting
UC San Diego / Moores Cancer CenterLa Jolla, California, United StatesNot Yet Recruiting
UC San Diego Koman Family Outpatient PavilionLa Jolla, California, United StatesNot Yet Recruiting

+ 116 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07227415