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Study identifier: NCT07227402 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

Condition: Renal Cell Carcinoma  ·  Sponsor: Merck Sharp & Dohme LLC

PhasePhase 3
Planned participants904
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Researchers are looking for more ways to treat advanced renal cell carcinoma (RCC) that is recurrent. Researchers want to learn if recurrent advanced renal cell carcinoma (RCC) responds (gets smaller or goes away) after treatment with belzutifan (MK-6482) and zanzalintinib compared to cabozantinib. The goal of this study is to learn if: People who take belzutifan and zanzalintinib live longer overall and without the cancer getting worse than people who take cabozantinib.

This description comes directly from the study's public registry record.

Talk to the study team

Toll Free Number  ·  1-888-577-8839  ·  Trialsites@msd.com

Always discuss trial participation with your own doctor first.

Locations (124)

Alaska Oncology and Hematology ( Site 0133)Anchorage, Alaska, United StatesRecruiting
Providence Medical Foundation ( Site 0141)Fullerton, California, United StatesRecruiting
Cedars-Sinai Medical Center ( Site 0112)Los Angeles, California, United StatesRecruiting
New England Cancer Specialists ( Site 0132)Westbrook, Maine, United StatesRecruiting
Greater Baltimore Medical Center ( Site 0145)Baltimore, Maryland, United StatesRecruiting
Metro-Minnesota Community Clinical Oncology ( Site 0144)Saint Louis Park, Minnesota, United StatesRecruiting
Oncology Hematology West P.C. dba Nebraska Cancer Specialists ( Site 0131)Omaha, Nebraska, United StatesRecruiting
Carolina Oncology Specialists, PA ( Site 9002)Charlotte, North Carolina, United StatesRecruiting
Thompson Cancer Survival Center ( Site 0125)Knoxville, Tennessee, United StatesRecruiting
Hospital Aleman ( Site 0204)CABA, Buenos Aires, ArgentinaRecruiting
Hospital Italiano de Buenos Aires. ( Site 0203)Caba, Buenos Aires, ArgentinaRecruiting
Asociación de Beneficencia Hospital Sirio Libanés ( Site 0205)Caba, Buenos Aires, ArgentinaRecruiting

+ 112 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07227402