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Study identifier: NCT07227012 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.

Condition: Carcinoma, Hepatocellular · Hepatocellular Cancer · Hepatocellular Carcinoma  ·  Sponsor: Pfizer

PhasePhase 1/Phase 2
Planned participants138
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to learn about the effects of study medicine (PF-08634404) when given alone or with another antibody (ipilimumab) for the treatment of a type of liver cancer called hepatocellular carcinoma (HCC) that is either locally advanced (spread to nearby tissues) or has spread to other parts of the body. To join the study, participants must meet the following conditions: * Be 18 years or older. * Have locally advanced or metastatic HCC. * Is not a candidate for complete surgical or loco-regional therapies. * Have not received any whole-body treatment for HCC. Participants will receive PF-08634404 either alone or in combination with ipilimumab. The medicine will be given through intravenous (IV) infusions, which means it will be administered directly into a vein. All treatments will take place at clinical trial sites, where trained medical staff will monitor participants during and after each visit.

This description comes directly from the study's public registry record.

Talk to the study team

Pfizer CT.gov Call Center  ·  1-800-718-1021  ·  ClinicalTrials.gov_Inquiries@pfizer.com

Always discuss trial participation with your own doctor first.

Locations (49)

Keck Hospital of USCLos Angeles, California, United StatesRecruiting
Los Angeles General Medical CenterLos Angeles, California, United StatesRecruiting
USC/Norris Comprehensive Cancer Center / Investigational Drug ServicesLos Angeles, California, United StatesRecruiting
USC/Norris Comprehensive Cancer CenterLos Angeles, California, United StatesRecruiting
Keck Medical Center of USC PasadenaPasadena, California, United StatesRecruiting
Moffitt Cancer Center at SperosLand O' Lakes, Florida, United StatesRecruiting
Moffitt Cancer Center at SouthShoreRuskin, Florida, United StatesRecruiting
Moffitt Cancer Center - International PlazaTampa, Florida, United StatesRecruiting
Moffitt Cancer Center - McKinley CampusTampa, Florida, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
Moffitt McKinley HospitalTampa, Florida, United StatesRecruiting
Moffitt Cancer Center at Wesley ChapelWesley Chapel, Florida, United StatesRecruiting

+ 37 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07227012