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Study identifier: NCT07226440 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Examining a Novel Gastrointestinal Intervention to Negate Environmental Toxicants (ENGINE)

Condition: Toxicant Exposure · Firefighter · Occupational Exposure to Chemicals  ·  Sponsor: University of California, San Francisco

PhasePhase 1/Phase 2
Planned participants50
Who can joinMale, 18 Years to no upper limit
Healthy volunteersNo

About this study

This randomized, placebo-controlled crossover trial will test the feasibility and acceptability of using colesevelam in male firefighters with high per- and polyfluoroalkyl substances (PFAS) exposure. This trial will also explore whether colesevelam lowers blood PFAS levels and urine environmental toxicant and mold mycotoxin levels.

This description comes directly from the study's public registry record.

Talk to the study team

Ashley Mason, PhD  ·  415-514-6820  ·  enginestudy@ucsf.edu

Leena Pandya, ND  ·  415-502-1619  ·  leena.pandya@ucsf.edu

Always discuss trial participation with your own doctor first.

Locations (1)

UCSF Osher Center for Integrative HealthSan Francisco, California, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07226440