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Study identifier: NCT07226076 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Methadone in TKA for Post-op Pain and Opioid Reduction

Condition: Post Operative Pain  ·  Sponsor: Medical University of South Carolina

PhasePhase 3
Planned participants162
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.

This description comes directly from the study's public registry record.

Talk to the study team

Haley Nitchie, MHA  ·  843-792-1869  ·  nitchie@musc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

Medical University of South CarolinaCharleston, South Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07226076