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Study identifier: NCT07224971 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Impact of Circadian Rhythm on Immunotherapy

Condition: Advanced/Metastatic NSCLC  ·  Sponsor: Liza Villaruz, MD

PhasePhase 2
Planned participants350
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study aims to determine whether morning versus afternoon treatment impacts efficacy of (standard of care) immunotherapy in a broad patient population. Patients with any type of advanced/metastatic malignancy are eligible to enroll in this study, as long as first-line anti-PD-1/PD-L1 immunotherapy is on label for their condition. Participants will then be randomized to either the early treatment group (administration must start and conclude by 11:00 AM +1 hour window) or the late treatment group (administration must start after 12:00 PM).

This description comes directly from the study's public registry record.

Talk to the study team

Jennifer Ruth, RN  ·  412-623-8963  ·  ruthj2@upmc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

UPMC Hillman Cancer CenterPittsburgh, Pennsylvania, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07224971