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Study identifier: NCT07224438 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Kisspeptin Administration Subcutaneously to Patients With Hypothalamic Amenorrhea

Condition: Hypothalamic Amenorrhea · Hypogonadotropic Hypogonadism  ·  Sponsor: Stephanie B. Seminara, MD

PhasePhase 2
Planned participants20
Who can joinFemale, 18 Years to 45 Years
Healthy volunteersNo

About this study

The goal of this study is to see whether kisspeptin, a naturally occurring hormone, can stimulate the release of other reproductive hormones in women with hypothalamic amenorrhea (HA). The investigators are also examining whether kisspeptin can help women release eggs from their ovaries. Kisspeptin will be administered subcutaneously (SC) for two weeks in a pulsatile fashion. Ultrasound monitoring of ovarian follicular growth and frequent blood sampling (every 10 minutes for up to two hours) will be performed to assess the physiologic response to kisspeptin over time.

This description comes directly from the study's public registry record.

Talk to the study team

Study Coordinator  ·  617-643-2308  ·  MGHKisspeptinResearch@partners.org

Always discuss trial participation with your own doctor first.

Locations (1)

Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07224438