Condition: Diabetes (DM) · Sponsor: David D'Alessio, M.D.
Glucagon secretion from α-cells has long been viewed as primarily a counterregulatory mechanism - e.g. an agent with a role to prevent blood sugar from decreasing to levels that compromise function. Our group, along with other researchers, have begun to identify a much more complex role for α-cells, raising questions about when and how glucagon may influence blood glucose levels. This proposal looks to detail proglucagon peptide secretion from α-cells and the impact this has on β-cell function and glucose tolerance, in preclinical studies of human islets and translational studies in human subjects. This protocol registration describes Aim 2 from this NIH grant which involves 2 study populations and separate protocols but addresses a common question. Aim 3 in the grant is focused on a separate hypothesis and will be conducted and published separately from Aim 2.
This description comes directly from the study's public registry record.
Johanna Johnson, MS · 919-660-6766 · johanna.johnson@duke.edu
Alyssa Sudnick, MS · 919-660-6769 · alyssa.sudnick@duke.edu
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| Duke Center for Living | Durham, North Carolina, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07224334