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Study identifier: NCT07222761 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM)

Condition: Relapsed and/or Refractory Multiple Myeloma (RRMM)  ·  Sponsor: Regeneron Pharmaceuticals

PhasePhase 3
Planned participants915
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study is researching a drug called linvoseltamab (also called "study drug") either given alone or in combination with another anti-myeloma drug called carfilzomib, compared to several standard treatments for progressive Multiple Myeloma (MM) after at least 1 but no more than 3 prior therapies. The aim of this study is to see if the safety and efficacy of linvoseltamab alone or in combination with carfilzomib can deliver better outcomes (deeper and longer responses that help extend life) than standard treatment options. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)

This description comes directly from the study's public registry record.

Talk to the study team

Clinical Trials Administrator  ·  844-734-6643  ·  clinicaltrials@regeneron.com

Always discuss trial participation with your own doctor first.

Locations (20)

Emory Winship Cancer InstituteAtlanta, Georgia, United StatesRecruiting
Memorial Sloan Kettering Cancer CenterNew York, New York, United StatesRecruiting
OhioHealthColumbus, Ohio, United StatesRecruiting
University of Texas Health Science Center, HoustonHouston, Texas, United StatesRecruiting
Mater Misericordiae LtdBrisbane, Queensland, AustraliaRecruiting
Gold Coast Hospital and Health ServiceSouthport, Queensland, AustraliaRecruiting
Alfred HospitalMelbourne, Victoria, AustraliaRecruiting
Chonnam National University Hwasun HospitalHwasun, Jeollanam-do, South KoreaRecruiting
Seoul National University HospitalSeoul, South KoreaRecruiting
Severance Hospital; Division of HematologySeoul, South KoreaRecruiting
Asan Medical CenterSeoul, South KoreaRecruiting
Samsung Medical CenterSeoul, South KoreaRecruiting

+ 8 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07222761