Condition: Sarcoma · Childhood Osteosarcoma · Childhood Rhabdomyosarcoma · Sponsor: St. Jude Children's Research Hospital
RAD3CAR is a phase I study designed to evaluatethe safety of B7-H3-CAR T cells and lymphodepletion in combination with hypofractionated radiation therapy. Primary objective: \- To evaluate the safety of B7-H3-CAR T cell therapy after priming with hypofractionated radiation therapy (HFRT) and lymphodepleting chemotherapy in patients ≤ 21 years of age with relapsed/refractory B7-H3+ sarcomas. Secondary objectives: * To describe the antitumor activity of B7-H3-CAR T cells in combination with HFRT * To determine if B7-H3-CAR T cells traffic to tumor sites after combination treatment with HFRT
This description comes directly from the study's public registry record.
Rebecca Epperly, MD · 8662785833 · referralinfo@stjude.org
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| St. Jude Children's Research Hospital | Memphis, Tennessee, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07222735